The Study
Testosterone therapy is associated with reduced risk of acute kidney injury, kidney failure with renal replacement therapy, and cardiovascular events in men with diabetes and hypogonadism
This study found that men who got testosterone therapy tended to have fewer kidney and heart problems than men who didn’t — but we don’t know if the testosterone caused it. Maybe the men who got testosterone were healthier in other ways we didn’t measure.
Analysis score
Maximum 72 for a cohort study.
Where the score came from
This study looked at diabetic men with low testosterone and found those who took testosterone pills or shots had fewer heart attacks, strokes, kidney failures, and died less often than those who didn't.
Where does this study sit?
Systematic Reviews & Meta-analyses
Max 100Randomized Trials
Max 90Cohort Studies
Max 72Case-Control
Max 58Cross-Sectional
Max 44Case Reports & Series
Max 30Expert Opinion
Max 559 / 100
Quality score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — these are meaningful reductions in life-threatening events for a high-risk group.
- 2Testosterone users had: 19% less kidney failure, 7% less acute kidney injury, 15% less heart attack, 15% less death, 12% less stroke, and 9% less atrial fibrillation over 3.3 years.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Cardiovascular Diabetology
Year
2025
Authors
F. Bonnet, Patricia Vaduva, J. Halimi, Arnaud Dosda, P. Ducluzeau, Laetitia Koppe, Laurent Fauchier
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.