The Study
Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice[S]
This study looked at mice fed special fats and saw some changes in their livers, but we don’t know if the scientists made fair comparisons or controlled everything. So we can’t say these fats cause liver damage — we can only say they might be linked to some changes in mice.
Analysis score
Maximum 72 for a cohort study.
Where the score came from
When soybean oil is heated, it makes harmful chemicals that can damage liver cells and cause inflammation in mice.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 59 / 100
Quality score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes - if similar effects happen in humans, eating repeatedly heated vegetable oils might worsen liver disease.
- 2Mice fed oxidized oil had less energy in liver cells, more damaged fats, more cell death, and more inflammation markers.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Journal of Lipid Research
Year
2018
Authors
Susanne Schuster, Casey D. Johnson, Marie Hennebelle, T. Holtmann, A. Taha, I. Kirpich, A. Eguchi, C. Ramsden, B. Papouchado, C. McClain, A. Feldstein
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.