Bad cooking oil can hurt your liver
Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice[S]
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
OXLAM-fed mice had lower liver triglycerides — yet still developed liver damage.
Most people assume fatty liver = lots of fat stored in the liver. But here, damage happened even with less fat — meaning it's not about fat quantity, but toxin-induced cellular chaos.
Practical Takeaways
Avoid reusing cooking oils — especially soybean, corn, or sunflower oil — and discard oil that looks dark, smells off, or smokes at low heat.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
OXLAM-fed mice had lower liver triglycerides — yet still developed liver damage.
Most people assume fatty liver = lots of fat stored in the liver. But here, damage happened even with less fat — meaning it's not about fat quantity, but toxin-induced cellular chaos.
Practical Takeaways
Avoid reusing cooking oils — especially soybean, corn, or sunflower oil — and discard oil that looks dark, smells off, or smokes at low heat.
Publication
Journal
Journal of Lipid Research
Year
2018
Authors
Susanne Schuster, Casey D. Johnson, Marie Hennebelle, T. Holtmann, A. Taha, I. Kirpich, A. Eguchi, C. Ramsden, B. Papouchado, C. McClain, A. Feldstein
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Claims (6)
When you cook with soybean oil, heat can turn it into a harmful chemical called 4HNE, which can damage your cells' energy factories and cause long-term body inflammation.
When mice eat foods that contain broken-down parts of linoleic acid (a common fat), their livers show more signs of damage from harmful molecules called free radicals.
When mice eat foods that contain certain broken-down fats called OXLAMs, their liver cells start having trouble making energy, their energy factories (mitochondria) make more copies of themselves, and some of the mitochondria’s DNA ends up floating in the wrong part of the cell.
When mice eat certain fats that have gone bad, their liver cells get stressed and start dying off because of a chain reaction inside their cells.
When mice eat foods that contain certain broken-down fats called OXLAMs, their livers show more signs of inflammation because key inflammation-triggering proteins become more active.