Do diabetes medicines help with sadness and liver health in older Black veterans?
SAT-536 How Do Metabolic Dysfunction Associated Steatosis Liver Disease (MASLD) and Depression in Veterans with T2DM respond to novel medications
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Patients on SGLT2 inhibitors had significantly lower BMI than those on GLP-1RAs, despite both being weight-loss-promoting drugs.
GLP-1 drugs like semaglutide are often marketed as superior for weight loss, yet users in this study were much heavier—by nearly 6 BMI points.
Practical Takeaways
If you have type 2 diabetes, depression, and fatty liver, discuss GLP-1 receptor agonists with your doctor as a potential option that may benefit multiple conditions.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Patients on SGLT2 inhibitors had significantly lower BMI than those on GLP-1RAs, despite both being weight-loss-promoting drugs.
GLP-1 drugs like semaglutide are often marketed as superior for weight loss, yet users in this study were much heavier—by nearly 6 BMI points.
Practical Takeaways
If you have type 2 diabetes, depression, and fatty liver, discuss GLP-1 receptor agonists with your doctor as a potential option that may benefit multiple conditions.
Publication
Journal
Journal of the Endocrine Society
Year
2025
Authors
Shannen Nicole Dean Ubalde, Jessica Khoury, Sabyasachi Sen
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Claims (6)
Older Black male veterans with diabetes, fatty liver, and depression who take GLP-1 drugs like semaglutide have slightly lower depression scores than those on SGLT2 drugs, but the difference isn’t big enough to be sure it’s not just by chance.
Older Black male veterans with diabetes, liver issues, and depression who take SGLT2 inhibitor pills tend to weigh less than those on GLP-1 shots, even though both types of medicine usually help people lose weight.
Older Black male veterans with type 2 diabetes have similar blood sugar levels no matter which common diabetes medicine they take—like metformin, insulin, or newer drugs like Ozempic or Farxiga.
Older Black male veterans with diabetes, fatty liver, and depression who take GLP-1 drugs (like Ozempic) seem to have less liver scarring than those on SGLT2 drugs, based on a blood test score — but the difference isn’t strong enough to be sure it’s not just by chance.
In older Black male veterans with diabetes, fatty liver, and depression, how bad their depression is doesn't seem to be linked to how much scarring their liver has — especially if they're taking certain diabetes meds like GLP-1 drugs or SGLT2 inhibitors.