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When a depression drug made things worse
Original Title
Paradoxical Depressive Response to Intranasal Esketamine in Treatment-Resistant Depression: A Case Series
doi:10.12659/AJCR.94547520%
Lower Quality
Methodology score · 20/100
Case Report Human
Fit Body Science breakdown
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What’s the bottom line?
Two people with severe depression felt better at first after using a nasal spray called esketamine, but then got much sadder and thought about hurting themselves. When they stopped the spray, they felt better again.
Score breakdown, methodology, COI, evidence analysis & raw study data
Publication
Authors
Ontiveros-Sánchez de la Barquera JA, De La Garza García LA, Esquivel García SV, Sánchez Torres G, Perez Jalomo GA