Why some LDL is worse than others
LDL atherogenicity determined by size, density, oxidation, apolipoprotein(a), and electronegativity: an updated review
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Not all bad cholesterol is the same—some types are sneakier and stickier, causing more damage to your arteries.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 51 / 5
Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Not all bad cholesterol is the same—some types are sneakier and stickier, causing more damage to your arteries.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 51 / 5
Evidence Score
Based on clinical experience or non-systematic literature reviews. The lowest level of evidence as they are most susceptible to bias and personal perspective.
Publication
Authors
Akyol O, Chiang HH, Burns AR, Yang CY, Woodside DG, Sawamura T, Sánchez-Quesada JL, Gotto AM, Chen CH
Related Content
Claims (6)
Lp(a) is a weird cholesterol particle that looks like a clotting protein, which makes blood harder to clot properly and carries toxic oxidized fats that inflame arteries.
Tiny, dense cholesterol particles stick around longer in the blood and slip more easily into artery walls, where they get damaged and trigger inflammation that leads to clogged arteries.
When cholesterol particles get damaged by free radicals, they turn into a toxic form that sticks to artery walls, tricks immune cells into eating them until they burst, and causes swelling and inflammation that worsens plaque.
Elevated low-density lipoprotein (LDL) cholesterol levels directly promote atherosclerotic plaque formation, increasing the risk of cardiovascular events.
A toxic form of LDL with a strong negative charge damages the inner lining of arteries by triggering cell death and attracting inflammatory cells, making plaque more unstable.