Oral semaglutide helps people with diabetes lose fat and keep muscle
Oral semaglutide improves body composition and preserves lean mass in patients with type 2 diabetes: a 26-week prospective real-life study
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Muscle-to-visceral fat ratio improved at 3 months but not at 6 months.
You’d expect improvements to continue or plateau, not dip back. This suggests the body may adapt or that longer-term effects need more study.
Practical Takeaways
If you have type 2 diabetes, ask your doctor if oral semaglutide could help you lose fat, improve liver health, and lower blood pressure.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Muscle-to-visceral fat ratio improved at 3 months but not at 6 months.
You’d expect improvements to continue or plateau, not dip back. This suggests the body may adapt or that longer-term effects need more study.
Practical Takeaways
If you have type 2 diabetes, ask your doctor if oral semaglutide could help you lose fat, improve liver health, and lower blood pressure.
Publication
Journal
Frontiers in Endocrinology
Year
2023
Authors
Sara Volpe, G. Lisco, Margherita Fanelli, Davide Racaniello, Valentina Colaianni, Valentina Lavarra, Domenico Triggiani, L. Crudele, V. Triggiani, Carlo Sabbá, Giovanni De Pergola, Giuseppina Piazzolla
Related Content
Claims (9)
Peptides marketed for fat loss often lack robust human evidence, relying instead on animal data or short-term biomarkers without long-term clinical validation.
Taking oral semaglutide for 6 months helped lower blood sugar levels in 32 people with type 2 diabetes, reducing their HbA1c by about 9% on average.
Half of the 32 people with type 2 diabetes who took oral semaglutide for 6 months lost at least 5% of their body weight.
After 3 months of taking oral semaglutide, 32 people with type 2 diabetes saw a better balance between muscle mass and belly fat, which improved further by 6 months but wasn't statistically significant.
In a group of 32 people with type 2 diabetes, taking oral semaglutide for 6 months led to a noticeable drop in body fat, with an average loss of about 17.6% of their initial fat mass.