How collagen talks to cells to help heal your body
The Molecular Interaction of Collagen with Cell Receptors for Biological Function
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
LAIR-1 receptor inhibits bone breakdown and immune responses when bound to collagen
People assume collagen only builds things, but it also has 'brakes' to prevent overactivity—like a built-in safety switch for bone health and immune balance
Practical Takeaways
Use collagen-based biomaterials with specific receptor-targeted designs for better wound healing or bone implants
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
LAIR-1 receptor inhibits bone breakdown and immune responses when bound to collagen
People assume collagen only builds things, but it also has 'brakes' to prevent overactivity—like a built-in safety switch for bone health and immune balance
Practical Takeaways
Use collagen-based biomaterials with specific receptor-targeted designs for better wound healing or bone implants
Publication
Journal
Polymers
Year
2022
Authors
Elango J, Hou C, Bao B, Wang S, Maté Sánchez de Val JE, Wenhui W
Related Content
Claims (10)
Collagen peptides function as signaling molecules that activate gene expression pathways responsible for collagen synthesis and tissue remodeling.
Two types of receptors (DDR1 and DDR2) on cell surfaces get turned on when collagen binds to them, which then starts chains of chemical signals inside the cell that control growth and survival.
Platelets use a receptor called GPVI to grab onto collagen through specific amino acid patterns (GPO), which starts the blood clotting process to stop bleeding.
A receptor called OSCAR on bone cells binds collagen to help form bone-resorbing cells (osteoclasts), which is crucial for bone remodeling.
A receptor called LAIR-1 stops bone breakdown and immune reactions when it binds to collagen, helping maintain balance in the body.