Does burnt food make your blood vessels sick?
Dietary intake of advanced glycation end products did not affect endothelial function and inflammation in healthy adults in a randomized controlled trial.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave people two kinds of diets—one with lots of browned, grilled food (high AGEs), and one with steamed or boiled food (low AGEs)—to see if eating burnt food harms your body.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
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Max 72Case-Control Studies
Max 58Cross-Sectional Studies
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Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave people two kinds of diets—one with lots of browned, grilled food (high AGEs), and one with steamed or boiled food (low AGEs)—to see if eating burnt food harms your body.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 560 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
Semba RD, Gebauer SK, Baer DJ, Sun K, Turner R, Silber HA, Talegawkar S, Ferrucci L, Novotny JA
Related Content
Claims (6)
Eating more or fewer AGEs—chemicals found in grilled or fried foods—for six weeks doesn’t seem to change inflammation levels in healthy people aged 50 to 69, so short-term diet changes like this probably don’t affect body-wide inflammation.
Eating more of the kinds of foods that have extra AGEs—like grilled or fried meats—for six weeks doesn’t seem to raise the levels of a specific marker in the blood or urine of healthy middle-aged and older adults, meaning those foods probably don’t make your body’s AGE burden much worse than it already is.
If you eat the same amount of food with the same carbs, fats, and calories—but just change how many AGEs (chemicals formed when food is cooked at high heat) are in it—for six weeks, your blood sugar, cholesterol, and related body signals don’t change. So, those cooked-food chemicals probably don’t mess with your metabolism in the short term.
Eating lots of or very little of certain foods that have AGEs (like grilled or fried foods) for six weeks doesn’t seem to change how well your small blood vessels work in healthy people aged 50 to 69.
If you're a healthy adult between 50 and 69 and you eat less of certain grilled, fried, or processed foods for 6 weeks, your body shows about 11% less of a harmful compound in your blood and 44% less in your urine—meaning what you eat really can lower this marker of aging and inflammation.