A brake receptor called LAIR-1 on immune cells binds collagen and turns off signals that would otherwise make bone-eating cells or immune cells too active.
Scientific Claim
LAIR-1 is an inhibitory collagen receptor expressed on NK cells and osteoclast precursors that suppresses immune activation and osteoclastogenesis by recruiting SHP-1/SHP-2 phosphatases to dephosphorylate ITAM signaling components.
Original Statement
“LAIR-1 is an inhibitory receptor actuated by triple-helical collagen as a ligand through interaction with the collagen-related peptide, triplet (glycine-proline-hydroxyproline GPO)10... The phosphorylation of LAIR-1 containing two ITIMs recruits phosphatases SHP-1 and 2 and directly dephosphorylates Zap70, PLCγ and Syk, inhibiting ITAM-mediated stimulation of protein kinases and calcium signaling.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The review synthesizes prior findings but does not establish direct causal control. 'Suppresses' and 'inhibiting' imply definitive functional outcomes not proven by a narrative review.
More Accurate Statement
“LAIR-1 is associated with binding collagen and is correlated with suppression of immune activation and osteoclastogenesis through recruitment of SHP-1/SHP-2 phosphatases that dephosphorylate ITAM signaling components based on prior experimental studies.”
Evidence from Studies
Supporting (0)
Contradicting (1)
This study talks generally about how collagen interacts with cells for things like medical materials, but it never mentions LAIR-1 or how it stops immune cells and bone cells from activating, so it doesn't help prove or disprove the claim.