A compound called 8-prenylnaringenin (8-PN) was found to fully stop bone loss in rats that had their ovaries removed - these rats are used to study a condition similar to osteoporosis that happens to women after menopause.

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Evidence from Studies

Supporting (1)

6

Community contributions welcome

6

Tissue specificity of 8-prenylnaringenin: protection from ovariectomy induced bone loss with minimal trophic effects on the uterus.

Cohort Study

Animal

2005 Nov

The study tested the same compound (8-PN) in the same type of animals (ovariectomized rats) and found it completely protected against bone loss, exactly as the claim states.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Tissue specificity of 8-prenylnaringenin: protection from ovariectomy induced bone loss with minimal trophic effects on the uterus.

Score: 6

DOI: 10.1016/J.JSBMB.2005.05.009

Similar Assertions

This claim is about a compound called 8-prenylnaringenin (found in hops) and how it affects the uterus and uterine lining in rats that had their ovaries removed. The claim says it has very small growth effects on these tissues, and importantly, these effects don't change no matter how much of the compound is given.

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76%

A compound found in hops called 8-prenylnaringenin (8-PN) appears to be much weaker at stimulating the uterus and uterine lining than the hormone estrogen, even when both are given at doses that protect bones equally well.

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Researchers found that a plant compound called 8-prenylnaringenin specifically works on bone tissue, confirmed by using special genetically modified mice that light up when the compound is active in bones.

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72%