The Claim
1,25-dihydroxyvitamin D3 strongly up-regulates the human cathelicidin antimicrobial peptide (CAMP) gene in myeloid cells, including acute myeloid leukemia cell lines, immortalized keratinocytes, colon cancer cells, and normal human bone marrow-derived macrophages, through binding to a vitamin D response element in the CAMP promoter, revealing a direct molecular mechanism linking vitamin D to innate immune regulation in primates.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Vitamin D activates a gene in certain human immune cells that helps fight off germs, and this happens because vitamin D directly attaches to a specific spot on the gene to turn it on.
See the scientific wording
1,25-dihydroxyvitamin D3 strongly up-regulates the human cathelicidin antimicrobial peptide (CAMP) gene in myeloid cells, including acute myeloid leukemia cell lines, immortalized keratinocytes, colon cancer cells, and normal human bone marrow-derived macrophages, through binding to a vitamin D response element in the CAMP promoter, revealing a direct molecular mechanism linking vitamin D to innate immune regulation in primates.
What the research says
1 studyThis study shows that a form of vitamin D turns on a human gene that helps fight germs, and it does so in immune cells exactly as claimed — by attaching to a specific spot on the gene’s DNA.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.