The Claim

In obese adults with non-alcoholic fatty liver disease (NAFLD), a 7-day isocaloric low-carbohydrate diet with increased protein intake is associated with downregulation of hepatic fatty acid synthesis genes (including FASN) and upregulation of fatty acid oxidation and folate-mediated one-carbon metabolism pathways, as demonstrated by liver biopsy transcriptomic analysis in a second cohort of 7 participants.

Source: An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
44score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

Eating fewer carbs and more protein for a week might help turn off fat-making genes and turn on fat-burning and metabolism genes in the livers of obese people with fatty liver disease.

See the scientific wording

In obese adults with NAFLD, a 7-day isocaloric low-carbohydrate diet with increased protein is associated with downregulation of hepatic fatty acid synthesis genes (including FASN) and upregulation of fatty acid oxidation and folate-mediated one-carbon metabolism pathways, as shown in liver biopsy transcriptomics from a second cohort of 7 participants.

What the research says

1 study
  1. Study: An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

    The study looked at what happens in the liver when people with fatty liver eat fewer carbs and more protein for a week, and it found changes in genes that help burn fat and reduce fat production, just like the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

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