The Claim

Selenite supplementation at 100 nM increases glutathione peroxidase activity by 178% in HT29 colon carcinoma cells and by 284% in P31 mesothelioma cells, without altering catalase activity, demonstrating selective upregulation of selenium-dependent antioxidant enzymes in human cancer cell lines.

Source: Effects of variation in glutathione peroxidase activity on DNA damage and cell survival in human cells exposed to hydrogen peroxide and t-butyl hydroperoxide.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
40score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

When human colon and mesothelioma cancer cells are exposed to 100 nM selenite, the activity of glutathione peroxidase increases significantly, while catalase activity remains unchanged, indicating a specific effect on one selenium-dependent enzyme.

See the scientific wording

Selenite supplementation at 100 nM increases glutathione peroxidase activity by 178% in HT29 colon carcinoma cells and by 284% in P31 mesothelioma cells, without altering catalase activity, demonstrating selective upregulation of selenium-dependent antioxidant enzymes in human cancer cell lines.

What the research says

1 study
  1. Study: Effects of variation in glutathione peroxidase activity on DNA damage and cell survival in human cells exposed to hydrogen peroxide and t-butyl hydroperoxide.

    Scientists gave cancer cells a tiny amount of selenium, and it made one important antioxidant enzyme (glutathione peroxidase) much stronger — just like the claim said — while leaving another enzyme (catalase) unchanged.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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