The Claim
The E. coli B834 (DE3) methionine auxotroph strain detects and quantitatively estimates vitamin B12 concentrations as low as 50 picomolar in biological samples, enabling high-throughput screening of vitamin B12 production across bacterial strains without chromatographic equipment.
What the research says
Not yet evaluated
We are still looking at what the research says.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
A genetically modified strain of E. coli bacteria can measure vitamin B12 levels as low as 50 picomolar in biological samples, allowing rapid screening of vitamin B12 production in other bacteria without using costly chromatography machines.
See the scientific wording
The E. coli B834 (DE3) methionine auxotroph strain can detect and quantitatively estimate vitamin B12 concentrations as low as 50 picomolar in biological samples, enabling high-throughput screening of vitamin B12 production across bacterial strains without requiring expensive chromatographic equipment.
A special strain of E. coli bacteria cannot make its own methionine unless it gets vitamin B12. When vitamin B12 is present, the bacteria use it to turn a precursor into methionine, which lets them grow and multiply. The more vitamin B12 there is, the more the bacteria grow, and this growth can be measured as cloudiness in the liquid they grow in. This cloudiness tells you exactly how much vitamin B12 was in the sample.
What the research says
1 studyScientists used a special type of E. coli bacteria that needs vitamin B12 to grow, and watched how well it grew when exposed to tiny amounts of B12 in samples — this lets them measure B12 without expensive machines.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.