Analysis Version
v1
History
Back to Study: 'That's the Esketamine, Baby, there's Nothing You ...
correlational
Analysis v1
20
Pro
0
Against

A nasal spray called esketamine may quickly and lastingly help people with severe depression that hasn’t responded to other treatments — and it might also reduce thoughts of suicide.

Claim Language

Language Strength

association

Uses association language (linked to, correlated with)

The claim uses the phrase 'is associated with,' which indicates a statistical or observational link rather than a direct cause-and-effect relationship. This language avoids claiming that esketamine causes the reduction, only that the two are linked.

Context Details

Domain

medicine

Population

human

Subject

Intranasal esketamine

Action

is associated with

Target

rapid onset and persistent reduction in depressive symptoms, including suicidal ideation

Intervention Details

Type: pharmacological

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Evidence from Studies

Supporting (1)

20
20

'That's the Esketamine, Baby, there's Nothing You Can Do about It!' An Update on Glutamatergic System in Suicidal Depression.

Systematic Review
Human
2020

This study found that a nasal spray version of esketamine quickly and lastingly helps people with severe, hard-to-treat depression—especially those thinking about suicide—just like the claim says.

Contradicting (0)

0
No contradicting evidence found

Source Study

'That's the Esketamine, Baby, there's Nothing You Can Do about It!' An Update on Glutamatergic System in Suicidal Depression.

Score: 20
DOI: 10.2174/1568026620666200131100316

Similar Assertions

Taking esketamine through the nose doesn't seem to make suicidal thoughts any better or worse in adults with severe depression that hasn't responded to other treatments, no matter when they checked.

33
0
93%

In two people with severe depression that didn’t respond to other treatments, a nasal spray called esketamine made them feel better at first, but then their mood got worse again—like a quick high followed by a crash.

20
0
92%

Two people with severe depression that didn’t respond to other treatments felt better and had fewer thoughts of suicide right after they stopped using a nasal spray called esketamine—even though they felt worse while using it.

20
0
91%

Two people with severe depression that didn’t respond to other treatments felt better at first after using a nasal spray called esketamine, but then their depression and suicidal thoughts got much worse—until they stopped using the spray, and then they felt better again.

20
0
90%

We don’t yet know if a nasal spray called esketamine is safe and works well over a long time for people with severe depression who are at risk of suicide—more research is needed.

20
0
88%