We don’t yet know if a nasal spray called esketamine is safe and works well over a long time for people with severe depression who are at risk of suicide—more research is needed.
Claim Language
Language Strength
probability
Uses probability language (may, likely, can)
The phrase 'are needed to investigate' implies uncertainty and a call for future research, indicating that the claim does not assert certainty but suggests a likelihood or possibility that such studies should be conducted.
Context Details
Domain
medicine
Population
human
Subject
Further studies
Action
are needed to investigate
Target
the long-term efficacy and safety of intranasal esketamine in patients with treatment-resistant or major depressive disorder with imminent suicide risk
Intervention Details
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.
Evidence from Studies
Supporting (1)
The study looked at a nasal spray version of esketamine for people with severe depression who might try to hurt themselves, and it says we still need more long-term research to make sure it’s safe and works over time — which is exactly what the claim says.