In people with Cushing's disease, a specific ratio of steroid metabolites in urine is lower than normal, which suggests that the enzyme responsible for activating cortisone into cortisol is not working fully.

20

Pro

0

Against

Evidence from Studies

Supporting (1)

20

Community contributions welcome

20

Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion.

Case Report

Human

2002 Jan

This patient had too much cortisol in her blood due to a brain tumor, but she didn't look sick because her body couldn't turn cortisone into active cortisol well—like a broken converter. The study shows that a low urine ratio (THF+allo-THF/THE) proves this converter isn't working right.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion.

Score: 20

DOI: 10.1210/JCEM.87.1.8189

Similar Assertions

After surgery to treat Cushing's disease, some patients show very low levels of cortisol in the blood, reduced ability to convert cortisone to cortisol, and faster clearance of cortisol from the bloodstream, suggesting a partial deficiency in the enzyme 11beta-HSD1.

20

0

77%

Some people with high levels of cortisol in their blood do not show the typical physical signs of Cushing's disease, such as weight gain or bruising, which may be due to their bodies converting less cortisone into active cortisol in tissues.

20

0

74%