The Claim
Polygenic risk scores for testosterone and bioavailable testosterone do not predict the rate of decline in serum testosterone levels over a 4.3-year period in men aged 58, indicating that common genetic variants influencing baseline testosterone levels do not determine the rate of age-related testosterone decline.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Genetic scores based on common variants that affect testosterone levels at a single point in time do not predict how quickly those levels decrease over time in men around age 58.
See the scientific wording
Polygenic risk scores for testosterone and bioavailable testosterone do not predict the rate of decline in serum levels over a 4.3-year period in men aged 58, indicating that common genetic variants influencing baseline levels do not determine how quickly testosterone declines with age.
As men age, the brain's signal to the testes to produce testosterone weakens, and the testes become less responsive to that signal, causing testosterone levels to drop — this process happens regardless of how high or low a man's testosterone was when he was younger due to his genes.
What the research says
1 studyStudy: 8039 Role Of Genetics In The Age-Related Testosterone Decline In Men: A UK Biobank Study
Just because someone is born with genes that give them high testosterone doesn’t mean they’ll lose it faster or slower as they get older — the study found genes don’t predict how fast testosterone drops. What matters more is things like health and lifestyle.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.