mechanistic
Analysis v1
Strong Support
In fat cells that burn energy to make heat, there might be a cycle where creatine gets charged up and then drained over and over, releasing energy as heat and keeping the cells' energy engines running.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
1
Mechanism of futile creatine cycling in thermogenesis.
Narrative Review
In Vitro
2020 Nov 1The study shows that in fat cell mitochondria, creatine can drive a cycle that burns energy and produces heat, just like the claim says, by repeatedly turning creatine into another molecule and back again.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.