Back to Study: Effect of dietary additives on intestinal permeabi...
correlational
mixed effect
A probiotic bacteria called Lactobacillus rhamnosus can either make the gut more or less leaky in human gut cells in a lab setting, depending on how much sugar is present.
Scientific Claim
Lactobacillus rhamnosus (a probiotic bacterium) can modulate intestinal permeability in human intestinal cell co-cultures depending on glucose concentration.
Source Excerpt
“Under control culture conditions, L. rhamnosus increased the permeability of the model; however, in combination with HS medium, L. rhamnosus caused a decrease in LY permeability when compared to epithelial co-cultures without bacteria (Fig. 6A).”
Evidence from Studies
Supporting Studies
Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture
Cannot Determine
View study →3%
Evidence Assessment
Supported
The study exposed human gut cells to L. rhamnosus with or without high glucose, finding that the bacteria had opposite effects on permeability depending on glucose concentration.