Sugar and additives can hurt your gut barrier
Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists tested how food additives affect the gut's protective barrier using fruit flies and human cells in a dish. They found sugar makes the gut leaky, while some additives like salt and emulsifiers also cause leaks. Probiotics can help but depend on sugar levels.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 5Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists tested how food additives affect the gut's protective barrier using fruit flies and human cells in a dish. They found sugar makes the gut leaky, while some additives like salt and emulsifiers also cause leaks. Probiotics can help but depend on sugar levels.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 5Publication
Journal
Disease Models & Mechanisms
Year
2018
Authors
M. T. Pereira, Mridu Malik, Jillian A Nostro, Gretchen J. Mahler, L. P. Musselman
Related Content
Claims (10)
Eating a lot of sugar makes the gut more leaky in fruit flies and human gut cells in a lab setting, which can be seen when blue dye leaks out of the gut in flies or when a special dye passes through gut cells more easily.
Eating a lot of sugar makes a protective enzyme called intestinal alkaline phosphatase less active in fruit flies and human gut cells in a lab setting.
A common food emulsifier called TWEEN 20 makes the gut more leaky in fruit flies and also makes them die sooner.
Eating a lot of salt makes the gut more leaky in fruit flies and also makes them die sooner.
A common food additive called titanium dioxide nanoparticles doesn't seem to make the gut more leaky in fruit flies or human gut cells in a lab setting.