Eating a lot of sugar makes a protective enzyme called intestinal alkaline phosphatase less active in fruit flies and human gut cells in a lab setting.

Scientific Claim

High sugar consumption is associated with reduced intestinal alkaline phosphatase (IAP) activity in both Drosophila melanogaster and human intestinal cell co-cultures.

Source Excerpt

“We found that high sugar reduced IAP activity in both models.”

Evidence from Studies

Supporting Studies

Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture

Cannot Determine

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Evidence Assessment

Supported

The study measured IAP activity in fly guts and human cell co-cultures after high sugar exposure, finding significant reductions in both models.

Source Study

Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture

Score: 3

DOI: 10.1242/dmm.034520

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