The bacteria in the gut interact with sugar to affect how leaky the gut is in fruit flies and human gut cells in a lab setting.

Scientific Claim

The gut microbiome interacts with dietary sugar to influence intestinal permeability in both Drosophila melanogaster and human intestinal cell co-cultures.

Source Excerpt

“To determine whether commensal bacteria play a role in sugar-dependent gut barrier dysfunction, we modulated the microbiome in the in vitro and in vivo models... Our results with the surfactant TWEEN 20 also coincide with what is known about the effects of these surface-tension-lowering compounds on gut permeability.”

Evidence from Studies

Supporting Studies

Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture

Cannot Determine

View study →

Evidence Assessment

Supported

The study manipulated the microbiome using antibiotics and L. rhamnosus, finding that bacterial presence affected sugar's impact on gut permeability in both models.

Source Study

Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture

Score: 3

DOI: 10.1242/dmm.034520

Similar Assertions

When fruit flies eat normal food, removing their gut bacteria makes their gut more leaky, but when they eat a lot of sugar, removing gut bacteria doesn't change gut leakiness.

85% similar

Eating a lot of sugar makes the gut more leaky in fruit flies and human gut cells in a lab setting, which can be seen when blue dye leaks out of the gut in flies or when a special dye passes through gut cells more easily.

83% similar

Eating a lot of sugar makes fruit flies have smaller guts and smaller bodies overall.

71% similar

Eating a lot of sugar makes a protective enzyme called intestinal alkaline phosphatase less active in fruit flies and human gut cells in a lab setting.

71% similar