A special form of lithium called lithium orotate may help the brain clear out harmful proteins linked to Alzheimer’s, fix memory problems, and reduce brain inflammation in mice—without using high, potentially toxic doses.

A form of lithium called lithium orotate may help fix low lithium levels in the brain, slow down harmful brain changes linked to Alzheimer’s, and even clean up the sticky proteins that cause memory problems in mice.

When mice don’t get enough lithium in their food, their brains lose about half their lithium, and this causes brain changes that look a lot like Alzheimer’s disease—like sticky protein clumps, damaged nerve connections, and memory problems.

When mice don’t get enough lithium, a brain enzyme called GSK3β goes into overdrive and causes damage linked to Alzheimer’s—like sticky protein clumps and broken brain connections—but giving them a drug that blocks this enzyme fixes those problems.

When mice don’t get enough lithium, their brain cells change their gene activity in ways that look a lot like the changes seen in human brains with Alzheimer’s—suggesting lithium might play a similar role in both species.

In people with early memory problems or Alzheimer’s, clumps of a protein called amyloid-beta act like sponges that soak up lithium—a mineral that might help protect brain cells—leaving less lithium where it’s needed, which could make brain damage worse.