The Claim
A porous frustoconical micropost array applied to pig skin under a weak electric field enables transdermal delivery of molecules up to 10 kDa by mechanically stretching the stratum corneum without penetration, demonstrating that molecular size limits for transdermal delivery can be exceeded through physical deformation combined with electroosmotic flow.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
A structured micropost array on pig skin, combined with a weak electric field, allows molecules up to 10 kDa to pass through the outer skin layer by stretching it physically, without breaking the skin, showing that larger molecules can be delivered transdermally using mechanical deformation and electrically driven fluid flow.
See the scientific wording
A porous frustoconical micropost array applied to pig skin under a weak electric field enables transdermal delivery of molecules up to 10 kDa by mechanically stretching the stratum corneum without penetration, demonstrating that molecular size limits for transdermal delivery can be exceeded through physical deformation combined with electroosmotic flow.
Tiny posts press gently on the skin’s outer layer and stretch it without breaking it, creating gaps between the skin cells. Electricity pulls fluid and large molecules through those gaps, letting big drugs pass through that normally could not.
What the research says
1 studyScientists made tiny, blunt, hole-filled posts that press gently on skin and use a weak electric current to pull big drug molecules through the skin’s outer layer—without poking it. This lets huge molecules, 20 times bigger than usual, get through just by stretching the skin and using electricity.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.