Scientists found that a specific gene called ptpn6 (or Shp1) is more active than usual in zebrafish babies with insulin resistance, which goes against what usually happens to immune genes when there's too much insulin.

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Evidence from Studies

Supporting (1)

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Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.

Cross-Sectional Study

Animal

2014 Aug

The study shows that when zebrafish larvae are exposed to high insulin levels (hyperinsulinemia), they become insulin-resistant and most immune genes are turned down. However, one specific gene called ptpn6 is actually turned UP, which is the opposite of the other immune genes - exactly matching what the claim says.

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Source Study

Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.

Score: 6

DOI: 10.1530/JOE-14-0178

Similar Assertions

Scientists found that turning off a specific gene called ptpn6 can fix the problems that too much insulin causes in baby zebrafish - specifically, it helps restore their immune system and insulin signaling that get messed up when there's too much insulin.

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A protein called Ptpn6 helps control whether the body can respond to insulin properly or becomes insulin-resistant in zebrafish with high insulin levels.

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