Scientists found that a specific genetic change called A554V in a protein called DNMT1 makes it stick to DNA about 8 times tighter than normal.

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Evidence from Studies

Supporting (1)

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Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1

Cross-Sectional Study

In Vitro

2023 Sep

The study directly confirms that the A554V mutation in DNMT1 increases DNA binding affinity by about 8-fold, exactly matching the claim. The researchers tested this specific mutation and found it reduces the dissociation constant from 4.6 μM to 0.55 μM, which is approximately an 8-fold increase in binding affinity.

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Source Study

Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1

Score: 4

DOI: 10.3390/dna3030010

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