A natural compound called PD 098063 can block a specific signal that makes blood vessel cells stick to immune cells—this might help reduce inflammation—without messing with other similar signals.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on transcription factor NF-kappa B.

Cross-Sectional Study

In Vitro

1996 Dec

Scientists tested a specific plant compound called PD 098063 on human blood vessel cells and found it blocks one inflammatory marker (VCAM-1) but not another (ICAM-1), exactly as the claim says — and it works best at a dose of 19 micromoles per liter.

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on transcription factor NF-kappa B.

Score: 4

DOI: 10.1161/01.ATV.16.12.1501

Similar Assertions

When scientists add a stress signal to blood vessel cells in a dish, those cells start making a sticky protein that can cause inflammation—but two natural plant compounds, luteolin and apigenin, stop this from happening, especially at higher doses.

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A natural compound called 2-phenyl-chromene-4-one can block a specific inflammatory signal in blood vessel cells, just like another known compound—this means it’s not the only one that can do this trick.

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79%

When scientists add certain plant compounds called luteolin and apigenin to blood vessel cells that are stirred up by an inflammation signal, fewer immune cells stick to them—kind of like stopping sticky notes from clinging. Other similar plant compounds usually don’t help, except for quercetin, which helps a little.

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