How a plant chemical stops sticky cells from starting artery clogs
Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on transcription factor NF-kappa B.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
PD 098063 reduces VCAM-1 by blocking gene transcription without affecting NF-kappa B, the most well-known pathway for this protein.
For decades, scientists assumed NF-kappa B was the only major switch for VCAM-1 expression in inflamed endothelial cells—this study shows a completely independent pathway exists.
Practical Takeaways
Eat more flavonoid-rich foods like berries, dark chocolate, and green tea—some may contain compounds similar to PD 098063.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
PD 098063 reduces VCAM-1 by blocking gene transcription without affecting NF-kappa B, the most well-known pathway for this protein.
For decades, scientists assumed NF-kappa B was the only major switch for VCAM-1 expression in inflamed endothelial cells—this study shows a completely independent pathway exists.
Practical Takeaways
Eat more flavonoid-rich foods like berries, dark chocolate, and green tea—some may contain compounds similar to PD 098063.
Publication
Journal
Arteriosclerosis, thrombosis, and vascular biology
Year
1996
Authors
J. Wölle, R. R. Hill, E. Ferguson, L. Devall, Bharat K. Trivedi, Roger S. Newton, Uday Saxena
Related Content
Claims (6)
A natural compound called PD 098063 can block a specific signal that makes blood vessel cells stick to immune cells—this might help reduce inflammation—without messing with other similar signals.
A chemical called PD 098063 tells the cells lining your arteries to make less of a specific protein signal (VCAM-1) by slowing down how fast the gene for that signal is turned on — it doesn’t change how quickly the signal’s instructions get broken down.
A chemical called PD 098063 can stop a harmful inflammation signal (TNF) from making a sticky protein (VCAM-1) that attracts immune cells, but it doesn’t mess with the main alarm system (NF-κB) that usually turns on this protein—so it’s blocking the result without turning off the alarm.
A natural compound called 2-phenyl-chromene-4-one can block a specific inflammatory signal in blood vessel cells, just like another known compound—this means it’s not the only one that can do this trick.
A chemical called PD 098063 can turn down a protein (VCAM-1) that helps inflammation, but it doesn’t do this by blocking the usual inflammation switch (NF-kappa B)—it uses a different, unknown path instead.