A chemical called PD 098063 tells the cells lining your arteries to make less of a specific protein signal (VCAM-1) by slowing down how fast the gene for that signal is turned on — it doesn’t change how quickly the signal’s instructions get broken down.

4

Pro

0

Against

Evidence from Studies

Supporting (1)

4

Community contributions welcome

4

Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on transcription factor NF-kappa B.

Cross-Sectional Study

In Vitro

1996 Dec

The study tested a chemical called PD 098063 in human blood vessel cells and found it lowers VCAM-1 gene activity by slowing down how fast the gene is read, not by breaking down the message faster — exactly what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on transcription factor NF-kappa B.

Score: 4

DOI: 10.1161/01.ATV.16.12.1501