A specific protein called integrin α2β1 attaches to certain types of collagen (I, II, XI) using a particular amino acid sequence (GFOGER), which helps cells stick to collagen and communicate with it.

Scientific Claim

Integrin α2β1 binds to collagen types I, II, and XI via the GFOGER motif sequence.

Original Statement

“The interaction of collagen with integrin α2β1 is synchronized by the collagen sequence GFOGER. It was reported that the interaction of collagens such as type I, II and XI with platelet integrin α2β1 is materialized by the GFOGER motif even without stimulators.”

From study:The Molecular Interaction of Collagen with Cell Receptors for Biological Function

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The molecular binding interaction is a well-documented fact supported by experimental evidence from prior studies, making definitive language appropriate.

Evidence from Studies

Supporting (1)

The Molecular Interaction of Collagen with Cell Receptors for Biological Function

Narrative Review

2022 Feb 23

Contradicting (0)

No contradicting evidence found

Source Study

The Molecular Interaction of Collagen with Cell Receptors for Biological Function

Score: 1

DOI: 10.3390/polym14050876

Similar Assertions

When collagen binds to integrin α1β1, it starts a chain reaction inside the cell that makes cells grow and move, which is important for healing and tissue repair.

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