The Claim
Recombinant human TSH induces a strong cyclic AMP response in differentiated orbital fibroblasts from patients with Graves' ophthalmopathy but does not stimulate significant hyaluronan synthesis in 11 out of 12 tested cultures.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In cells taken from patients with Graves' ophthalmopathy, recombinant human TSH triggers a strong increase in cyclic AMP but does not cause significant hyaluronan production in most cultures.
See the scientific wording
Recombinant human TSH induces a strong cyclic AMP response in differentiated orbital fibroblasts from patients with Graves' ophthalmopathy but fails to stimulate significant hyaluronan synthesis in all but one of 12 tested cultures.
When the TSH hormone binds to its receptor on eye tissue cells, it turns on a chemical signal called cAMP, but this signal does not turn on the production of the swelling-causing goo called hyaluronan, except in rare cases.
What the research says
1 studyIn eye cells from people with Graves' eye disease, the hormone TSH makes a chemical called cAMP spike, but it usually doesn't make the gooey substance (hyaluronan) that causes swelling — except in one out of twelve cases.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
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