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v1
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Back to Study: Autoantibodies to selenoprotein P in chronic fatig...
correlational
Analysis v1
Strong Support

A specific type of antibody that targets selenoprotein P is found in a higher percentage of people with chronic fatigue syndrome than in people without the condition.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone

Case-Control Study
Human
2023 Sep

Scientists found that a small group of people with chronic fatigue syndrome have unusual antibodies that interfere with how selenium moves in the body, and these antibodies are much rarer in healthy people. This suggests that for some people with chronic fatigue, their symptoms might be linked to this specific biological problem.

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No contradicting evidence found

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Source Study

Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone

Score: 54
DOI: 10.1016/j.redox.2023.102796

Similar Assertions

In people with chronic fatigue syndrome who have specific autoantibodies, selenium in the blood does not correlate with the activity of an enzyme called glutathione peroxidase 3, suggesting that selenium is not reaching the kidneys properly even though overall selenium levels in the body are normal.

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78%

People with chronic fatigue syndrome who have autoantibodies targeting selenoprotein P show lower levels of markers indicating thyroid hormone conversion to its active form, compared to those without these autoantibodies.

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77%

People with chronic fatigue syndrome who have specific antibodies targeting selenoprotein P excrete less iodine in their urine than those without these antibodies or healthy individuals, suggesting a reduction in the release of iodide from thyroid hormones caused by decreased deiodinase enzyme function.

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71%