For people with diabetes who don’t have serious artery disease, adding a drug called evolocumab to their usual cholesterol medicine lowers bad cholesterol a lot — down to 52, compared to 111 without it — after a year.

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Pro

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Against

Evidence from Studies

Supporting (1)

55

Community contributions welcome

55

Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes

Randomized Controlled Trial

Human

2026 Mar 28

The study shows that adding evolocumab to statins in diabetic adults without severe artery disease lowers bad cholesterol to 52 mg/dL, much lower than the 111 mg/dL seen with placebo, just as the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes

Score: 55

DOI: 10.1001/jama.2026.3277

Similar Assertions

For people with diabetes but no major heart artery disease, adding a drug called evolocumab to their cholesterol medicine might lower their chance of dying over five years — 7.8% of those on the drug died, compared to 10.1% on a placebo.

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91%

For people with diabetes who are at high heart risk but don’t yet have serious artery disease, adding a drug called evolocumab to their cholesterol medicine (statin) cuts their chance of having a first heart attack, stroke, or heart-related death by about a third over nearly 5 years.

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0

91%

For people with diabetes who are at high heart risk but don’t yet have major artery blockages, adding a drug called evolocumab to their usual cholesterol medicine cuts their chance of heart attack, stroke, or heart-related death by about a third over nearly 5 years.

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90%

For people with heart disease who are already taking cholesterol-lowering pills, adding a drug called evolocumab can slash their bad cholesterol by about 60% in less than a year—bringing it down to very low levels.

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88%

Even if your cholesterol is already pretty low thanks to statins, adding a drug called evolocumab can still help protect your heart and blood vessels.

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88%