In rat liver cells, a type of fat called palmitate boosts sugar production just as much as a stress hormone does, and adding both together doesn’t do more — suggesting they work through the same switch in the cell.

15

Pro

0

Against

Evidence from Studies

Supporting (1)

15

Community contributions welcome

15

Enhanced glucose production in norepinephrine and palmitate stimulated hepatocytes following endurance training

Cross-Sectional Study

Animal

2024

The study shows that both palmitate and norepinephrine increase sugar production in liver cells, which supports the idea that they both play a role, but it doesn’t test if they work through the same pathway.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Enhanced glucose production in norepinephrine and palmitate stimulated hepatocytes following endurance training

Score: 15

DOI: 10.3389/fphys.2024.1514082

Similar Assertions

In female rats that were trained for endurance, their liver cells used more lactate to make glucose when stimulated, and this extra fuel use completely explains why they made more glucose—meaning the key change was how much lactate got into the cells, not how fast the cells processed it.

15

0

74%

Female rats that did treadmill training for 10 weeks made more glucose in their liver cells, even when resting and without hormones, compared to rats that didn’t train.

15

0

72%