People who received the shingles vaccine had a lower rate of heart attacks, strokes, and other serious heart problems over eight years compared to those who did not.
Mechanism
Synthesis from 1 study
The shingles vaccine helps keep the virus that causes shingles from waking up in the body. When the virus stays quiet, it causes less long-term inflammation, which in turn makes blood vessels healthier and less likely to trigger heart attacks or strokes.
Most probable mechanism
Getting the shingles vaccine helps keep the virus that causes shingles from reactivating, which in turn reduces ongoing low-level inflammation in the body. This lower inflammation makes it less likely for blood vessels to get damaged or for clots to form, which lowers the chance of heart attacks and strokes.
Live attenuated shingles vaccine induces immune memory against varicella-zoster virus, reducing viral reactivation in sensory ganglia
Reduced viral reactivation decreases chronic activation of innate immune pathways and pro-inflammatory cytokine production
Lower systemic inflammation reduces endothelial dysfunction, vascular plaque instability, and thrombotic potential
Evidence from Studies
Supporting (1)
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Contradicting (0)
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