The Claim

Higher perceived stress, as measured by the Perceived Stress Index (PSI), is associated with a significantly increased prevalence of non-alcoholic fatty liver disease (NAFLD) in apparently healthy adults, with individuals in the 90th percentile of stress (PSI score 27) having approximately 1.8 times higher odds of NAFLD compared to those in the 10th percentile (PSI score 10), after adjusting for age, sex, BMI, metabolic factors, and lifestyle variables.

Source: Author Correction: Perceived stress and non-alcoholic fatty liver disease in apparently healthy men and women

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
39score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

Adults with higher self-reported stress levels have a higher rate of non-alcoholic fatty liver disease compared to those with lower stress levels, even when accounting for age, sex, body weight, and lifestyle factors.

See the scientific wording

Higher perceived stress, as measured by the Perceived Stress Index (PSI), is associated with a significantly increased prevalence of non-alcoholic fatty liver disease (NAFLD) in apparently healthy adults, with individuals in the 90th percentile of stress (PSI score 27) having approximately 1.8 times higher odds of NAFLD compared to those in the 10th percentile (PSI score 10), after adjusting for age, sex, BMI, metabolic factors, and lifestyle variables.

Why this might work

When a person feels stressed for a long time, the body releases stress hormones that tell fat cells to break down fat and send it to the liver, while also making the liver less able to respond to insulin. This causes fat to build up in the liver instead of being used or stored properly.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: Author Correction: Perceived stress and non-alcoholic fatty liver disease in apparently healthy men and women

    People who feel more stressed are more likely to have a fatty liver, even if they’re not overweight or have other health problems — this study found that link in healthy adults.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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