The Claim

Higher baseline plasma levels of erythritol and erythronate are associated with increased 10-year atherosclerotic cardiovascular disease risk scores in adults with overweight and obesity, with each standard deviation increase in erythritol linked to a 1.1% higher risk estimate after adjusting for BMI.

Source: Abstract MP28: Declines in Plasma Levels of Nonnutritive Sweetener Erythritol Are Related to Two-Year Improvements in Atherosclerotic Cardiovascular Disease Risk Estimates Among Adults With Overweight and Obesity

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
68score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

Adults with overweight or obesity who have higher levels of erythritol and erythronate in their blood have higher calculated 10-year risks of developing atherosclerotic cardiovascular disease, and each standard deviation increase in erythritol corresponds to a 1.1% increase in this risk estimate after accounting for body mass index.

See the scientific wording

Higher baseline plasma levels of erythritol and erythronate are associated with increased 10-year atherosclerotic cardiovascular disease risk scores in adults with overweight and obesity, with each standard deviation increase in erythritol linked to a 1.1% higher risk estimate after adjusting for BMI.

Why this might work

High levels of erythritol and erythronate in the blood damage the inner lining of blood vessels, trigger inflammation, and make it easier for fatty deposits to build up in artery walls, increasing the chance of heart disease.

Suggested mechanismbased on 1 study

What the research says

1 study
  1. Study: Abstract MP28: Declines in Plasma Levels of Nonnutritive Sweetener Erythritol Are Related to Two-Year Improvements in Atherosclerotic Cardiovascular Disease Risk Estimates Among Adults With Overweight and Obesity

    People with more erythritol in their blood at the start were more likely to have a higher risk of heart disease over 10 years, even if they were overweight — and when their erythritol levels went down after dieting, their heart risk improved too.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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