African-American kids with certain PCSK9 gene changes (Y142X or C679X) have lower 'bad' cholesterol from a young age—this finding is from the abstract summary - full study details were not available

Pro

Against

Evidence from Studies

Supporting (1)

Community contributions welcome

Relation of PCSK9 mutations to serum low-density lipoprotein cholesterol in childhood and adulthood (from The Bogalusa Heart Study).

Cohort Study

Human

2007 Jul 1

Contradicting (0)

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Relation of PCSK9 mutations to serum low-density lipoprotein cholesterol in childhood and adulthood (from The Bogalusa Heart Study).

Score: 45

DOI: 10.1016/J.AMJCARD.2007.02.057