The Claim

In untrained young men, a single bout of resistance exercise increases myofibrillar protein synthesis by 67% and mitochondrial protein synthesis by 69%, while a single bout of endurance exercise increases mitochondrial protein synthesis by 154% and has no effect on myofibrillar protein synthesis, demonstrating that acute exercise modality differentially regulates the synthesis rates of muscle protein fractions.

Source: Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
30score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

In untrained young men, one session of weight lifting raises the production of muscle structural proteins by 67% and energy-producing mitochondrial proteins by 69%, while one session of running raises mitochondrial protein production by 154% but does not change muscle structural protein production.

See the scientific wording

In untrained young men, a single bout of resistance exercise increases myofibrillar protein synthesis by 67% and mitochondrial protein synthesis by 69%, while endurance exercise increases mitochondrial protein synthesis by 154% but does not affect myofibrillar protein synthesis, indicating that acute exercise stimuli differentially activate the synthesis of muscle protein fractions based on training modality.

Why this might work

When you lift weights, the force on your muscles turns on a molecular switch that tells the cell to build more contractile proteins. When you run, the energy demand in your muscles turns on the same switch but only tells the cell to build more energy-producing parts. The same molecular pathway is used in both cases, but only one type of protein gets made depending on the kind of exercise.

Verified mechanismbased on 1 study

What the research says

1 study
  1. Study: Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle

    After one workout, weightlifting boosts the muscle fibers that make you stronger by 67% and the energy parts of muscle by 69%, while running only boosts the energy parts by 154% and leaves the strength fibers unchanged. This shows that different exercises turn on different parts of your muscles.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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