The Claim
High-dose vitamin C and E supplementation in young adults reduces the acute phosphorylation of p70S6K following resistance training, which is associated with diminished long-term muscle hypertrophy.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In young adults, taking high doses of vitamin C and E after weight training reduces a specific molecular signal involved in muscle growth, leading to less muscle growth over time.
See the scientific wording
In young adults, high-dose vitamin C and E supplementation blunts the acute phosphorylation of p70S6K—a key signaling protein in muscle protein synthesis—within hours after resistance training, suggesting a mechanistic link to reduced long-term hypertrophy.
After a workout, muscles produce molecules called reactive oxygen species that act as signals to turn on muscle growth. High doses of vitamin C and E remove these signals before they can activate key growth proteins. Without these signals, the main growth pathway in muscle cells stays inactive, so the muscle doesn't build new protein or get bigger over time.
What the research says
1 studyStudy: Can supplementation with vitamin C and E alter physiological adaptations to strength training?
Taking high doses of vitamin C and E after weight training seems to interfere with the body’s natural muscle-building signals, leading to smaller muscle gains over time in young adults.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.