The Claim

In trained cyclists, post-exercise carbohydrate-protein supplementation does not significantly alter phosphorylation of p70(S6K) compared to placebo, despite increasing phosphorylation of upstream regulators mTOR and Akt.

Source: Post exercise carbohydrate–protein supplementation: phosphorylation of muscle proteins involved in glycogen synthesis and protein translation

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
46score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

In trained cyclists, consuming a carbohydrate-protein drink after exercise does not change the phosphorylation level of p70(S6K), even though it increases phosphorylation of mTOR and Akt.

See the scientific wording

In trained cyclists, post-exercise carbohydrate-protein supplementation does not significantly alter phosphorylation of p70(S6K) compared to placebo, despite increasing phosphorylation of upstream regulators mTOR and Akt, suggesting that p70(S6K) may not be a primary target of this supplement under these conditions.

Why this might work

After exercise, consuming carbohydrates and protein raises insulin and amino acid levels, which turn on Akt and mTOR proteins in muscle cells. These proteins then activate rpS6 to start building new proteins, but they do not change the activity of p70(S6K), even though p70(S6K) is normally linked to mTOR. This means the muscle starts protein production through a different route that skips p70(S6K).

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: Post exercise carbohydrate–protein supplementation: phosphorylation of muscle proteins involved in glycogen synthesis and protein translation

    After cycling, a sugar-and-protein drink turned on some muscle repair signals but didn’t affect one specific protein (p70(S6K)) that’s usually linked to muscle growth—meaning not all signals respond the same way to the drink.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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