The Claim
In obese adult women who have lost weight, fasting concentrations of peptide YY (PYY) and growth differentiation factor 15 (GDF-15) remain unchanged compared to pre-weight-loss levels.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In women who were obese and lost weight, the levels of two hormones called peptide YY and GDF-15 in the blood after fasting are the same as they were before weight loss.
See the scientific wording
After weight loss in obese adult women, fasting levels of peptide YY (PYY) and growth differentiation factor 15 (GDF-15) do not change significantly, suggesting these hormones may not play a major role in the biological drive to regain weight in this population.
After weight loss, the body lowers its energy use below what is expected from the new smaller size, and it increases hunger signals through certain hormones, but peptide YY and growth differentiation factor 15 do not change in the blood, meaning they are not part of the biological drive that pushes weight back up.
What the research says
1 studyAfter women lost weight, two appetite hormones called PYY and GDF-15 stayed the same, while others changed — so these two probably aren’t the main reason they started gaining weight again.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.