In rats, sore muscles after unusual exercise make a protein called NGF, which seems to cause pain sensitivity—blocking NGF quickly reduces soreness, and stopping another pain-related signal (bradykinin) also stops NGF from being made, suggesting it's part of the soreness chain reaction.

1

Pro

0

Against

Evidence from Studies

Supporting (1)

1

Community contributions welcome

1

Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness

Narrative Review

Animal

2024 Jan 24

The study shows that NGF plays a key role in muscle soreness after exercise in rats, and that it's activated by another pain-related molecule, which supports the idea that blocking NGF could reduce soreness.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness

Score: 1

DOI: 10.1186/s12576-023-00896-y

Similar Assertions

When you hurt a chewing muscle, your body might produce more of a protein called NGF, which could make the nerves in that muscle extra sensitive over time and lead to long-lasting pain.

1

0

79%

In rats, sore muscles after unusual exercise seem to start with a specific pain signal (called bradykinin) turning on right when the exercise happens. If you block that signal before exercise, the rats don’t get sore — but only if you block it early.

1

0

76%