When women with obesity stopped taking semaglutide, their gut bacteria changed in a way that’s linked to lower levels of a helpful bile acid and reduced activity in a brain region that helps control...

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Evidence from Studies

Supporting (1)

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Post-semaglutide weight regain in females with obesity: Associations with gut microbiota, bile acid metabolism, and central nervous system.

Cohort Study

Human & Animal

2026 Feb 18

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

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Source Study

Post-semaglutide weight regain in females with obesity: Associations with gut microbiota, bile acid metabolism, and central nervous system.

Score: 26

DOI: 10.1111/dom.70571

Similar Assertions

When people stop taking semaglutide, they often gain weight back and feel hungrier — and this might be because their gut bacteria and metabolism go back to how they were before, which could be telling their brain to eat more.

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