Everyone can build muscle with consistent strength training over time — if you didn’t gain muscle once, it’s probably not your genes, just that specific training phase didn’t work for you.
Evidence from Studies
Supporting (4)
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Repeated Resistance Training Reveals the Reproducibility of Muscle Strength and Size Responses Within Individuals
The study shows that people who don’t gain muscle in one training period often do in another, so not responding isn’t permanent or due to genetics.
Higher resistance training volume offsets muscle hypertrophy non-responsiveness in older individuals.
Some people don’t gain muscle with light training, but this study shows they can build muscle with more intense workouts, suggesting no one is truly unable to respond to training.
The study found that both healthy women and breast cancer survivors gained muscle from weight training, showing that most people can build muscle with exercise, even if they’ve had health challenges.
The study shows that even people over 85 years old can build muscle and get stronger with regular strength training, just like younger seniors. This supports the idea that almost everyone can gain muscle with effort, regardless of age or assumed limitations.
Contradicting (1)
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The study shows that some people’s bodies respond better to weight training than others, and this seems to be due to biological and possibly genetic differences, which goes against the idea that everyone can gain muscle equally with training.
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.