If someone with Alzheimer's has more ups and downs in their memory test scores early on, they might end up with more amyloid buildup in the brain after getting a special ultrasound treatment that opens the blood-brain barrier multiple times.

Pro

Against

Evidence from Studies

Supporting (1)

Community contributions welcome

Extensive Frontal Focused Ultrasound-Mediated Blood-Brain Barrier Opening for the Treatment of Alzheimer’s Disease: An Open-Label Prospective Study

Cohort Study

Human

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Extensive Frontal Focused Ultrasound-Mediated Blood-Brain Barrier Opening for the Treatment of Alzheimer’s Disease: An Open-Label Prospective Study

Score: 25

DOI: 10.21203/rs.3.rs-3806289/v1

Similar Assertions

People with Alzheimer's who start off with worse symptoms and less amyloid in their brain might actually see more amyloid build-up after a special ultrasound treatment opens up the barrier in their brain.

88%

Some Alzheimer's patients had a special ultrasound treatment to open part of their brain, and in most of them, brain scans showed less of a harmful protein linked to the disease.

84%

Doing three brain treatments using focused ultrasound in Alzheimer's patients, two months apart, seems safe and doable, with no serious side effects seen right after the procedures.

74%