In adults with overweight or obesity who do not have diabetes, the medication orforglipron lowers systolic blood pressure by an average of 7.1 mmHg more than other similar medications in the same...
Mechanism
Synthesis from 1 study
This drug makes the kidneys get rid of more salt and water, while also turning down a hormone that squeezes blood vessels. Together, this lowers the pressure in the arteries more than other similar drugs. It also reduces some inflammation in blood vessels, but that’s a smaller part of why the...
Most probable mechanism
A drug activates receptors in the kidneys that cause the body to flush out more salt and water, while also lowering a hormone that tightens blood vessels. This combination reduces pressure inside the arteries.
GLP-1 receptors in the renal tubules are activated, increasing sodium and water excretion into the urine
GLP-1 receptor activation inhibits renin release from the kidneys, reducing the production of angiotensin II
Lower levels of angiotensin II cause blood vessels to relax, decreasing peripheral vascular resistance
Less supported by current evidence, but not ruled out
Reducing inflammation in blood vessels helps them relax and function better, which lowers pressure.
GLP-1 receptors on immune cells in blood vessel walls are activated, suppressing the release of inflammatory signals
Lower levels of inflammatory markers reduce oxidative stress and improve the ability of blood vessels to dilate
Evidence from Studies
Supporting (1)
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Contradicting (0)
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