Among Japanese adults aged 65 and older, those who experience social isolation tend to live about 69.5 days less over a 9.4-year period compared to those who are more socially connected, even when...
Mechanism
Synthesis from 1 study
Being alone for a long time keeps the body’s stress system turned on, which leads to more inflammation over time. This inflammation slowly harms the heart, blood vessels, and other organs, making it harder to live as long as someone who is socially connected.
Most probable mechanism
When someone is alone for a long time, their body stays in a state of low-level stress, which causes the stress hormone system to overwork. This leads to more inflammation in the body over time, which can damage organs and make it harder to stay healthy, eventually shortening life.
Chronic social isolation activates the hypothalamic-pituitary-adrenal axis, leading to sustained elevation of cortisol levels
Elevated cortisol promotes pro-inflammatory cytokine production and reduces anti-inflammatory signaling
Chronic systemic inflammation contributes to tissue damage, endothelial dysfunction, and accelerated aging of multiple organ systems
Evidence from Studies
Supporting (1)
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Contradicting (0)
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