Patients with multiple myeloma who take lenalidomide indefinitely have a higher rate of adverse events and second cancers than those who take it for only two years.
See the scientific wording
In patients with multiple myeloma, indefinite lenalidomide therapy is associated with a higher incidence of adverse events and second cancers compared to 2 years of lenalidomide therapy.
Very strong evidence
Mixed evidence2 high-quality studies support this claim.
What the research says
2 studies reviewedSupporting (2)
Continuous versus Fixed Duration Maintenance Therapy in Multiple Myeloma
Randomized Controlled TrialHuman2026
People with multiple myeloma who took lenalidomide forever had more side effects and more new cancers than those who stopped after two years, even though both groups lived about as long.
Evolution of clonal hematopoiesis on and off lenalidomide maintenance for multiple myeloma
Cohort StudyHuman2025
Taking lenalidomide for a long time can cause dangerous blood cell changes that may lead to other cancers, but stopping the drug after two years often makes these changes go away. So, longer use is riskier.
Contradicting (0)
No contradicting studies found yet
That doesn't mean it's settled — it just means no study has tested the opposite.
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Score breakdown, mechanism chain, raw evidence, ideal studies needed & 2 supporting studies
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